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DESCRIPTION

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SUBUTEX (buprenorphine) sublingual tablet is an uncoated oval white flat bevelled edged tablet, debossed with an alphanumeric word identifying the product and strength on one side. It contains buprenorphine HCl, a partial agonist at the mu-opioid receptor, and is available in two dosage strengths, 2 mg buprenorphine and 8 mg buprenorphine (as the free base, equivalent to 2.16 mg buprenorphine hydrochloride USP and 8.64 mg buprenorphine hydrochloride USP). Each tablet also contains lactose, mannitol, cornstarch, povidone K30, citric acid, sodium citrate and magnesium stearate.

Short-Term Effects

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Subutex is considered a long-acting opioid because the effects can last for up to 3 days.4 Because of this, the risks of negative effects are lower since they are more dispersed and less intense. For example, at higher doses Subutex is shown to have a lower risk of related breathing problems than some other drugs used for opiate addiction management, including methadone.4

Though the risk may be smaller, it can increase dramatically if Subutex is taken with other depressant drugs like benzodiazepines or alcohol.4 These substances in combination can lead to:5

  • Breathing problems.
  • Sedation.
  • Coma.
  • Death.

The short-term, desirable effects of Subutex include pain relief, a mild euphoria, and and a reduction in opioid cravings.4However, as with any other substance, there are dangers. Taking too much/abusing it can lead to:1,4

  • Sleepiness.
  • Confusion.
  • Nausea.
  • Respiratory depression.

Side Effects

Suddenly stopping use of Suboxone can elicit unpleasant withdrawal symptoms.

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Side effects that may occur during a period of active use include:6

  • Constipation.
  • Nausea and vomiting.
  • Muscle aches.
  • Insomnia.
  • Irritability.
  • Fever.

While Suboxone is used in the treatment of addiction, the drug itself can lead to tolerance and dependence. Suddenly stopping use of Suboxone can elicit unpleasant withdrawal symptoms, such as:7

  • Yawning.
  • Teary eyes.
  • Dilated pupils.
  • Restlessness.
  • Anxiety.

The inclusion of the opioid antagonist, naloxone, in the medication can send someone who attempts to inject it into what is known as precipitated withdrawal—the very rapid or immediate onset of opioid withdrawal

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